Background: Migraine is a chronic debilitating neurological disease that can interfere with a patient's quality of life and disturb daily routine chores. Migraine preventive therapy is crucial as acute treatment. Patients who suffer from frequent attacks with or without aura are a candidate for migraine prophylaxis. Objective: We aim to provide an overview of migraine and the role of gabapentin and pregabalin in migraine preventive therapy. Methodology: We searched in the PubMed database for relevant articles using the following Mesh terms: "Migraine," "Migraine preventive therapy," "Gabapentin," and "Pregabalin." Conclusion: Both gabapentin and pregabalin have antinociceptive properties. They worked by modulating the Calcium channel to enhance and increase the synthesis of GABA in the brain. Some data showed an excellent response to these drugs in terms of decrease migraine attack severity and frequency. Yet, the mechanism behind these effects is not clearly understood, and more randomized clinical trials are needed to establish their exact efficacy and safety on migraine prevention.".