Pharmacophore an International Research Journal
Pharmacophore
Submit Manuscript
Open Access | Published: 2012 - Issue 4

MODELING AND MOLECULAR DYNAMICS STUDIES ON ESP1 AND ESP6 EPITOPES OF EARLY SECRETED ANTIGENIC TARGET PROTEIN ESAT-6 FROM MYCOBACTERIUM TUBERCULOSIS Download PDF


Rohan J Meshram, Pratik P Vikhe, Asmita J Gavhane, Suresh N Jangle and Rajesh N Gacche
Abstract

Tuberculosis (TB) has emerged as one of the leading health problem since last three decades. High rate emergence of extremely multiple drug resistant Mycobacterium strains results in inefficiency of available prophylactic and therapeutic means. Hence there is an urgent need to search for alternative, safe, effective and affordable preventive as well as therapeutic strategies against TB. ESAT-6 is an early secreted protein by Mycobacterium tuberculosis that can be used as target for efficient peptide vaccine design against TB. In present study, initially new epitopes were identified using online epitope prediction tools and structural models of both ESP-1 and ESP-6 epitopes derived from ESAT-6 were developed. Later on these epitopes were used for molecular dynamics analysis. Results obtained from molecular dynamics analysis on ESP1 and ESP6 epitopes direct need to focus further study on their interaction with MHC molecules.

QR code:

Short Link:
Quick Access

Pharmacophore
ISSN: 2229-5402


Pharmacophore
© 2021 All rights reserved