The sudden outbreak of the 2019 novel coronavirus "Severe Acute Respiratory Syndrome coronavirus 2” (SARS-CoV-2) in Wuhan, China, has affected the healthcare system and economy by its rapidly worldwide spreading. The present review intends to describe some of the current molecular and immunological assays used in SARS-CoV-2 detection from an epidemiological perspective, highlighting the importance of rapid test development and improvement. In this purpose the database as Databases (NCBI/PubMed, medRxiv) were used for searching, identifying and synthesizing data regarding SARS-CoV2 diagnosis.This report presents the optimal assays that can discriminate between different stages of the infection pointing out their utility in diagnosis, treatment, and vaccine development. Taken into account SARS-CoV-2 pandemic evolution and the dynamic character of COVID-19 diagnostic assays, the development of a joint effort by the scientific community is necessary for identifying future diagnostic directions that might help the disease management.