Mushroom poisoning is the most common form of plant food poisoning. In childhood, poisoning with wild mushrooms often has an unfavorable prognosis due to the speed and depth of development of homeostatic disorders, which are due to the anatomical and physiological characteristics of the child's body, and the incompleteness of the formation of many of its systems. First of all, the cause of severe poisoning is the immaturity of the detoxification and elimination systems. Timely diagnosis, determination of the exact causes and mechanisms of poisoning, severity, and early treatment from the moment of poisoning are of the greatest importance in predicting treatment. Diagnosis of mushroom poisoning is very difficult since the general clinical picture of the disease is similar to the clinical picture of chemical poisoning of various etiologies. The duration of the rehabilitation period mainly depends on the initial severity of the pathological process. The purpose of this work was to consider the features of poisoning by poisonous mushrooms in children and adolescents and to study the principles of diagnosis and treatment of poisoning, as reflected in relevant literary sources.