The present study through transversal analysis reveals the profile of patients’ infection in the ICUs of a Tertiary care hospital. It aims at categorizing patients with a focus on the prevalence rates of infection, sites and types of infection, most prevalent bacteria and its antimicrobial resistance patterns, as well as identifying the risk factors for ICU acquired infection. One of the 50 patients admitted to ICU showed bacteremia due to Pseudomonas aeruginosa. This isolate might not necessarily have represented the cause of infection nevertheless regarding the isolates reported. The predominance of Gram negative bacilli P. aeruginosa was identified. Previous report, showed the predominance of Gram positive cocci Staphylococcus aureus, and Gram negative organisms P. aeruginosa.