Nasim Zamani1, 2, Ebrahim Hosseini3*, Mehrdad Modaresi4, Abdallah Ghasemi Pirbalouti5
Fertility and reproduction are from of the most important issues of communities. Considering the interaction of reproduction system and thyroid gland plus various behaviors of nanoparticles and their main materials, this study was carried out to investigate the perinatal effects of lithium carbonate nanoparticles on ovarian and thyroid textures and the amount of sexual and thyroid hormones in rats’ female progenies. Forty female pregnant rats were divided into control, placebo (0.5 ml of distilled water), 1.26 and 1.90mg/kg/bw doses of lithium carbonate nanoparticles. All injections were done intraperitoneal for twenty days. At the end of lactation period, female progenies were separated and ten rats were selected randomly from each group. Blood samples were taken and the amount of sexual and thyroid hormones were measured. Also, by separating thyroid and ovary glands, cell count was performed in these tissues. Results showed that nanoparticles reduced estrogen, progesterone, LH and FSH hormones in both doses and also reduced pre-antral and antral follicles, the number of corpus luteum and increased corrupted follicles significantly (P<0.01). On the other hand, these particles reduced T3, T4, thyroid follicles, epithelial height of follicles and nuclear TSH and colloidal space of follicles significantly (P<0.01). According to results, nanoparticles of lithium carbonate damaged performance and structure of pituitary-gonadal axis and pituitary-thyroid axis of rats.
