Persian Gulf methanolic extract of Nerita longi as efficient antioxidant agent Download PDF

Background: Marine organisms are the important key for the development and conception of new drugs with medicine applications. Marine invertebrates produce a high amount of natural products as adaptation to their environmental and as result of their life style. Marine natural compounds with powerful bioactivities were already extracted from marine invertebrates including gastropods, tunicates, sponges, soft corals, sea hares, sea cucumbers and bryozoans. Some of those compounds, have pharmaceutical activity such as antitumor, antimicrobial, anti-inflammatory and antioxidant activities which can be used in clinical and preclinical assays. Objectives: The purpose of this research was to examine the activity of methanolic extract from Persian Gulf gastropod, Nerita longi as efficient antioxidant. Materials and methods: Persian Gulf gastropod, Nerita longi was washed and macerated with ethyl acetate and methanol for three days. The resulting extracts were dry with freeze dryer and the final residue were consider for antioxidant tests by DPPH, FRAP and FOLIN methods. Results: In DPPH method, the resultant IC50 for methanol and ethyl acetate were 8.07 and 10.13 mg/ml, respectively. In FRAP method, the resultant EC1 for methanol and ethyl acetate were 3.687, 5.35 mg/ml respectively. In FOLIN method, the highest Absorbance in methanolic and ethyl acetate extracts are given 1.626 and 1.592. Conclusions: Muscle tissue of Persian Gulf gastropod, Nerita Longi, is an important source of natural proteins and peptides. So high antioxidant activity was given from FRAP, DPPH and FOLIN methods of methanolic extract can be related to the ability of methanol to extract corresponding peptides and proteins.