Antioxidantsresourced from stress adapted plants have medicinal properties or be toxic. Practical utilization of these as medicines need to explore the exact nature of discrimination of their actions. By testing their effects on blood composition one can judge well the health caring or toxic potential of antioxidants. In the present study, crude methanolic extracts containing antioxidants of some xerophytic herbs from the Cholistan desert of Pakistan were used to determine their in vitro effects on some hematological attributes like counts for granulocyte; leukocyte, lymphocyte; eosinophils; monocyte; granulocytes, Red Blood Cell, Mean Corpuscular, lymphocytes. Haemoglobin, Haemoglobin, Mean Corpuscular Haemoglobin, Concentration, Mean Corpuscular Volume, Packed Cell Volume, Hematocrit, and Red Cell Distribution. Data were analyzed statistically. Leucocytes, ranulocytes, haemoglobin, and monocytes increased by extracts. Eosinophils, platelets, and RBC were decreased. There were recorded some exceptions. Calotropis stem decreased leucocytes, monocytes, and granulocytes. Salsola leaves decreased monocytes. Hemoglobin was increased by Aerva stem extract. Platelets were increased by Haloxylon stem extract.