S. aureus is an opportunistic pathogen that causes a wide spectrum of different diseases in humans and animals. S. aureus infects the skin of rabbits, causing irritation of some dermal tissue suppurative dermatitis and invades subcutaneous tissues, causing different severe diseases and different physiological changes. The aim of this study is to update knowledge and information on rabbit Staphylococcosis by concentrating mostly on the various symptoms and studying the physiological changes under the effect of pharmaceuticals and extracts of herbal plants as treatments for infected rabbits. Isoteritonin was used as a pharmaceutical treatment, while extracts of Beta vulgaris L. (beetroot) and Kaempferia pandurate (Chinese ginger) were used as an herbal treatment.