Pharmacophore an International Research Journal
The purpose of this study was to evaluate the potential for floating drug delivery system (FDDS) of cefpodoxime proxetil chosen as model drug with an aim to prolong the gastric resident time of floating dosage form as well as increase total floating time. Direct compression method was used for preparation of floating tablets. The prepare formulation were evaluated for various parameters like hardness, thickness, average weight, floating lag time, total floating time, drug content, % cumulative drug release. In preliminary batches 3 polymers were used in combinations, from the obtained evaluation data of preliminary batches polymers (Plasdone S 630 & WSR 303) were selected for further factorial design batches, from the evaluation parameter data, tablets of all batches complied with the mass variation requirement of Indian Pharmacopoeia and here no batch variation > 5% of average weight which indicates that consistency in the preparation of the tablet having minimum batch to batch variation. There was proper distribution of the drug in the floating matrix tablets according to results of drug content analysis and well within the range of 95.95 -102.39 % of the total amount of the drug added in floating matrix tablets. Total floating time required by tablet was > 12 hrs and floating lag time was noted within 2-4 hr. It was concluded that formulation of cefpodoxime proxetil had potential application as antibiotic for sustained delivery of drug following in oral administration.
