Pharmacophore an International Research Journal
The goal of this research was to explore the underlying hepatoprotective mechanisms of Omega-3 fatty acids against liver toxicity in response to cadmium chloride exposure (Cd) in rats. Cd (5 mg /kg b.w) was ingested to rats daily for 6 days. Omega-3 fatty acids (100 mg/kg b.w.) were ingested orally to Cd intoxicated rats simultaneously with or before Cd intoxication daily for 6 days. Data revealed that administration of Omega-3 fatty acids simultaneously with or before Cd intoxication , significantly diminished the increases in hepatic malondialdehyde (MDA) and ameliorated the depletion in antioxidant enzymes, namely superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transfrease (GST). The fatty acids also attenuated the increase in hepatic 8-hydroxy-2'-deoxyguanosine (8-OHdG, index of DNA damage), interferon gamma (IFNγ), nuclear factor kappa B (NF-κB) and heat shock protein-70KDs (HSP-70). The existing biochemical investigations were confirmed by histo-cytologic observation. Conclusion: the present investigation propose that the hepatoprotective impacts of Omega-3 fatty acids against Cd caused liver toxicity in rats may ascribe to their anti-oxidative stress, antioxidant and anti-inflammatory beneficial actions.
