Pharmacophore an International Research Journal
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Open Access | Published: 2017 - Issue 5

Protective Mechanisms of Omega-3 Fatty Acids Against Hepatotoxic Impact of Cadmium Exposure in Rats Download PDF

Najla O. Ayaz

The  goal of this   research was to  explore  the  underlying   hepatoprotective  mechanisms  of   Omega-3 fatty acids   against  liver  toxicity  in response to  cadmium chloride  exposure  (Cd)  in rats. Cd   (5 mg /kg b.w) was ingested  to rats daily for 6 days. Omega-3 fatty acids  (100 mg/kg b.w.) were ingested  orally  to Cd intoxicated rats simultaneously with or before Cd intoxication  daily for 6 days. Data   revealed that administration  of Omega-3 fatty acids simultaneously with or before Cd intoxication , significantly  diminished the increases in hepatic  malondialdehyde (MDA) and ameliorated the depletion in antioxidant enzymes, namely superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transfrease (GST). The fatty acids also attenuated  the increase in hepatic 8-hydroxy-2'-deoxyguanosine  (8-OHdG, index  of DNA damage), interferon gamma (IFNγ), nuclear factor kappa B (NF-κB) and heat shock protein-70KDs (HSP-70). The existing biochemical investigations  were confirmed  by histo-cytologic  observation. Conclusion: the present investigation propose that the hepatoprotective impacts  of Omega-3 fatty acids against  Cd  caused liver  toxicity  in rats may ascribe  to their anti-oxidative stress,   antioxidant and  anti-inflammatory beneficial actions.

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ISSN: 2229-5402

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