Mental health and achieve that, is one of the critical issues in human life. Western psychologists have raised a number of indicators for the mental health. Islamic point of view of the mental health and illness due to their different ontological, theological, anthropological, and epistemological foundations with the Western principles, at the same there are some commonalities, can be distinguished. The aim of this research is criticizing and studying the concept of the mental health from the Western psychological view and providing a holistic concept of the mental health based on indicators of a healthy person in the Holy Quran. Material and Method: The present research methodology was qualitative. In this study Grounded Theory (GT) was used. To extract the mental health an index from the perspective of four human relations (with Allah, Self, Others and the Universe) was used the methods of coding (open, axial, selective) in Grounded Theory (GT) and also categories and concepts were clustered. Results: The results indicated that based on four human relations (with Allah, self, others and the Universe) can be provided a comprehensive explanation of the mental health. Moreover, in human relations with Allah (10), with self (12), with others (5) and with the Universe (3) indexes were extracted. Conclusion: From the perspective of the holy Quran, heart disease and mental health have been explained. In relation to the concepts of the mental health and heart disease, between the position of Islam and Western psychological perspective, both in definitions and in the indexes, despite some commonalities, have been reported fundamental differences. al health have been explained. In relation to the concepts of the mental health and heart disease, between the position of Islam and Western psychological perspective, both in definitions and in the indexes, despite some commonalities, have been reported fundamental differences.