Renal toxicity is a common disease worldwide. The current work was conducted to assess the possible renoprotective activity of Ipomoea batatas leaves extract (LB) in the cyclosporine (CE)-induced nephrotoxicity in rats. Forty male rats were distributed into 4 groups; Control (Cont), CE; rats intraperitoneal (IP) injected with CE (twenty-five mg/kg) for twenty-one days, LB 200 mg/ kg with +CE, LB 400 mg/ kg with +CE; rats received LB orally for twenty-one days, followed by IP injection with CE. Biochemical samples were collected after 24 h from the last dose of CE. The renal tissue samples were collected for histopathological examination. The results of the CE group showed that there were significant increases in renal lipid peroxidation (MDA), serum anti-inflammatory cytokines (TNF-α and IL-1β), serum kidney function parameters, and the serum ionic potassium (K+) level, with significant decreases in the renal superoxide dismutase (SOD) and serum ionic sodium ( Na+ ) compared with the control group. In addition, the renal tissues of the same group showing congestion, focal hemorrhage, and interstitial nephritis, with coagulating necrosis of the renal tubules compared with the control group. Oral administration of LB extract significantly ameliorated CE-induced renal oxidative stress. It reduced CE-induced elevation in serum anti-inflammatory cytokines and kidney function parameters, as well as the changes in ionic Na+ and K+ levels compared to the CE group. It also protected against CE-induced histopathological changes. Therefore, LB extract ameliorates nephrotoxicity caused by CE through antioxidant and anti-inflammatory mechanisms.