Literature study of quinoxaline gives idea about naturally occurring quinoxaline like echinomycin & triostin-A. Literature study reveals that anti-tubercular, antibacterial, antifungal, antimalarial, antiinflammatory & AMPA-NMDA receptor antagonist spectrum of activity. Quinoxalines are becoming the attractive target of extensive research due to its inherent diverse properties in future. In the recent year, 2, 3-disubstituted quinoxalines reported to possess significant antimicrobial potential against bacteria, fungi,and mycobacterium.