Pharmacophore an International Research Journal
Nootropic are class of psychotropic agent with selective facilitatory effect on integrative function of central nervous system, particularly on intellectual performance, learning capability and memory. Alzheimer disease is associated with decline in cognitive abilities. The most common causes of dementia in elderly is Alzheimer disease. The allopathic system is yet to provide satisfactory antidote, despite the severity and high prevalence of the disease. The cognitive effect of methanol extract of stem bark (100 and 200 mg/kg) was investigated using elevated plus maze apparatus by administering the extract in swiss albino wistar mice. Piracetam was taken as standard drug. The higher dose of plant extract decreases significantly the transfer latency as compared to control and exhibit the promising nootropic potential in a dose dependent way. In the present study phytochemical screening of methanol extract of Tephrosia purpurea confirm the presence of flavonoids, tannins and saponins, which may have been associated with central nervous system effect. Further investigations using more experimental paradigms are required for confirmation of nootropic potential cognitive disorder.
