Pharmacophore an International Research Journal
A sensitive and rapid extractive spectrophotometer method has been developed for the assay of carvedilol in bulk drug and tablets. The method is based on the formation of a chloroform soluble ion-pair complex between carvedilol and bromophenol blue in an acidic medium. The complex shows maximum absorbance at 414 nm. Beer’s law was obeyed in the concentration range of 5-20 μg /ml. Results of analysis were validated statistically and by recovery studies. The proposed method is now simple, new, reproducible, and accurate and successfully employed in routine analysis of carvedilol bulk drug and tablet dosage forms.
