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Open Access | Published: 2021 - Issue 6

Structure and Resistance of Microorganisms to Antimicrobial Drugs While Providing Medical Care to Patients with COVID-19 Download PDF


Konstantin Vyacheslavovich Zhmerenetskiy, Vadim Semenovich Gorokhovskii, Sergej Vladimirovich Dyachenko, Vladislav Dmitrievich Okhotnik
Abstract

The present article aims to study the structure of microorganisms and their resistance to antimicrobial drugs while providing in-hospital medical care to patients with COVID-19. С. Albicans 46.82% (n=375) and C.Glabrata 21.97% (n=176) (prevailed among monotypes of fungal infection. Str. Pneumonia 25.24% (n=617) antimicrobial association of Str. pneumonia + spp. Candida 11.17% (n=273) were the leaders in the frequency of selection among all microorganisms. The prevailing pathogens in deceased patients were: Kl. pneumonia 36.3% (n=159). Candida fungi 21.92% (n=96).The analysis of resistance to antimicrobial drugs showed that Streptococcus pneumonia (n=890) has low level of resistance to benzylpenicillin 4.2% (n=37), levofloxacin 11.5% (n=102), linezolid 0%, and at the same time a high level of resistance to erythromycin 27.4% (n=244), lincomycin 25.2% (n=224), doxycycline 15.5% (n=141).An overwhelming number of isolates of K.pneumoniae (n=326) was resistant to ampicillin 97.9%, cefuroxime 94.2%, cefotaxime 87.7%, ceftazidime 85% and cefepime 73% with rather low resistance to amoxicillin and clavulanic acid 52.1% (n=170) and meropenem 33.4% (n=109). The number of isolates of microorganisms with pan-resistance makes 7.6% (n=125). The maximum proportion among PDR strains of microorganisms comes from K. pneumonia and is amounted to 33.4% (n=109) from all isolates of Klebsiella. C. Albicans and Str. Pneumonia are the most often selected pathogens in patients with COVID-19 who are receiving in-hospital medical care. An increasing frequency of detection of Klebsiella spp. XDR and PDR strains lead to a necessity of a proper choice of drugs for empirical antibacterial therapy.

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Vancouver
Zhmerenetskiy K V, Gorokhovskii V S, Dyachenko S V, Okhotnik V D. Structure and Resistance of Microorganisms to Antimicrobial Drugs While Providing Medical Care to Patients with COVID-19. Pharmacophore. 2021;12(6):50-4. https://doi.org/10.51847/DCLeh9pb13
APA
Zhmerenetskiy, K. V., Gorokhovskii, V. S., Dyachenko, S. V., & Okhotnik, V. D. (2021). Structure and Resistance of Microorganisms to Antimicrobial Drugs While Providing Medical Care to Patients with COVID-19. Pharmacophore, 12(6),50-54. https://doi.org/10.51847/DCLeh9pb13

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