The present article aims to study the structure of microorganisms and their resistance to antimicrobial drugs while providing in-hospital medical care to patients with COVID-19. С. Albicans 46.82% (n=375) and C.Glabrata 21.97% (n=176) (prevailed among monotypes of fungal infection. Str. Pneumonia 25.24% (n=617) antimicrobial association of Str. pneumonia + spp. Candida 11.17% (n=273) were the leaders in the frequency of selection among all microorganisms. The prevailing pathogens in deceased patients were: Kl. pneumonia 36.3% (n=159). Candida fungi 21.92% (n=96).The analysis of resistance to antimicrobial drugs showed that Streptococcus pneumonia (n=890) has low level of resistance to benzylpenicillin 4.2% (n=37), levofloxacin 11.5% (n=102), linezolid 0%, and at the same time a high level of resistance to erythromycin 27.4% (n=244), lincomycin 25.2% (n=224), doxycycline 15.5% (n=141).An overwhelming number of isolates of K.pneumoniae (n=326) was resistant to ampicillin 97.9%, cefuroxime 94.2%, cefotaxime 87.7%, ceftazidime 85% and cefepime 73% with rather low resistance to amoxicillin and clavulanic acid 52.1% (n=170) and meropenem 33.4% (n=109). The number of isolates of microorganisms with pan-resistance makes 7.6% (n=125). The maximum proportion among PDR strains of microorganisms comes from K. pneumonia and is amounted to 33.4% (n=109) from all isolates of Klebsiella. C. Albicans and Str. Pneumonia are the most often selected pathogens in patients with COVID-19 who are receiving in-hospital medical care. An increasing frequency of detection of Klebsiella spp. XDR and PDR strains lead to a necessity of a proper choice of drugs for empirical antibacterial therapy.