Pharmacophore an International Research Journal
Introduction. This manuscript presents the results of studies acute toxicity of a drug “Flyblok insecticidal tag” (4% s-fenvalerate and 8% piperonyl butoxide). Materials and Methods: The studies were carried out on the basis of the Federal State Budgetary Educational Institution of Higher Education "Moscow State Academy of Veterinary Medicine and Biotechnology-MVA named after K.I. Scriabin ”and LLC“ Research and Development Center Agrovetzashchita”. Compounds that are used in veterinary medicine to combat blood-sucking insects. Studies were conducted on 36 white mice weighing 20-25g. and 36 guinea pigs, weighing 350-400g. Results: It was found that the average lethal dose of LD50 solution for drug impregnation in white mice with intragastric administration is 542.7 ± 283 mg/kg. The LD50 value of solution for drug impregnation, when applied to the guinea pigs on the clipped skin in the region of the vertebral column is 1874 ± 185 mg / kg. Сonclusion: According to the parameters of acute toxicity after intragastric administration to white mice and cutaneous application of guinea pigs to the skin, it was found that a solution for a drug impregnation according to the generally accepted hygiene classification n refers to substances that are moderately hazardous to animal health.
