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Open Access | Published: 2020 - Issue 4

Study of Acute Toxicity "Flyblok Insecticidal Tag" ‎ Download PDF


Аleksey V. Mironenko, Sergei V. Engashev, Alexander A. Deltsov, Fedor I. Vasilevich, Ekaterina S. Engasheva, Sergey V. Shabunin
Abstract

Introduction. This manuscript presents the results of studies acute toxicity of a drug “Flyblok insecticidal tag” (4% s-fenvalerate and 8% piperonyl butoxide). Materials and Methods: The studies were carried out on the basis of the Federal State Budgetary Educational Institution of Higher Education "Moscow State Academy of Veterinary Medicine and Biotechnology-MVA named after K.I. Scriabin ”and LLC“ Research and Development Center Agrovetzashchita”. Compounds that are used in veterinary medicine to combat blood-sucking insects. Studies were conducted on 36 white mice weighing 20-25g. and 36 guinea pigs, weighing 350-400g. Results: It was found that the average lethal dose of LD50 solution for drug impregnation in white mice with intragastric administration is 542.7 ± 283 mg/kg. The LD50 value of solution for drug impregnation, when applied to the guinea pigs on the clipped skin in the region of the vertebral column is 1874 ± 185 mg / kg. Сonclusion: According to the parameters of acute toxicity after intragastric administration to white mice and cutaneous application of guinea pigs to the skin, it was found that a solution for  a drug impregnation according to the generally accepted hygiene classification n refers to substances that are moderately hazardous to animal health.

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ISSN: 2229-5402

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