Pharmacophore an International Research Journal
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Open Access | Published: 2011 - Issue 1

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 2-SUBSTITUTED BENZOTHIAZOLES CONTAINING AZOMETHINE LINKAGE Download PDF


Balram Soni, Anil Bhandari, Mahendra Singh Ranawat, Peeyush Sharma, Rambir Singh, Sanjay Sharma, Ram Prakash Prajapat
Abstract

As part of ongoing studies in developing new antimicrobials, a novel series of N-(1, 3-benzothiazol-2-yl)-2-[(2Z)-2-(substituted arylidene) hydrazinyl] acetamide (5a–j) was synthesized in order to determine their antimicrobial activities. The synthesized compounds were tested in vitro against two Gram-positive, one Gram-negative bacteria and two fungal strains in comparison with control drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial activity against the tested microorganisms. The compounds with a 4-dimethylamino group (5j) and 4-amino group (5i) on the aromatic ring possessing azomethine linkage showed better antimicrobial activity; almost similar to that of standard drugs thus they could be promising candidates for novel drugs. The novel heterocycles were characterized by elemental analyses and spectral features.

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Pharmacophore
ISSN: 2229-5402


Pharmacophore
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