Pharmacophore an International Research Journal
Synthesis, characterization, antimicrobial activity and docking studies of 1, 2, 3-triazoles comprising a glucose and aryl moieties were reported. Majority of the compounds found to be active and few of them exhibited strong in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, P. aeruginosa, B. proteus, C. albicans and A. fumigatus. All the compounds were subjected to docking studies against S. aureus tyrosyl tRNA synthetase and Lanosterol-14-demethylase (CYP51). The docking study results demonstrated that, all are having considerable binding energies and have good affinity toward the active sites of the protein, thus, they may be considered as good inhibitors of tyrosyl tRNA synthetase and CYP51.
