Systemic and Vascular Inflammatory Response to Acute Aerobic Exercise in Patients with Coronary Artery Disease After Revascularization Intervention Download PDF

Background: cardiovascular revascularization interventions are frequently performed operations in patients with coronary artery disease (CAD) that induced inflammatory reactions, but systemic and vascular inflammatory response to acute exercise in these patients is controversial. The aim of this study is to investigate effects of one session aerobic exercise on systemic and vascular in-flammatory biomarkers in CAD patients after revascularization interventions. Methods: 65 male with CAD after coronary artery bypass grafting(CABG) and percutaneous coro-nary intervention (PCI) participated in our study and dedicate in intervention group (IG; n=35, age: 58.31±7.21 years) and control group (CG; n= 30, age: 57.9±7.4 years). Patients in IG per-formed one session acute aerobic exercise. Plasma levels of pentraxin3 (PTX3), VCAM-1 and C-reactive protein (CRP) measured at baseline and 30 minutes after acute aerobic exercise session include 30 minutes treadmill walking or running at 70% of HRmax in IG and at the same time for CG. Results: plasma levels of VCAM-1(558±207 vs. 633±138, p=0.049) and CRP (3.32±1.87 vs. 3.88±2.27, p=0.037) increased significantly in IG after acute aerobic exercise session but these changes were not statistically significant in comparison to CG. Plasma levels of VCAM-1 was significantly higher in IG than CG (592.7±151 vs. 534.8±88, p=0.042). There is no significant difference between plasma PTX3 levels before and after acute aerobic exercise in IG and in Com-pared to CG (p>0.05). Univariate analysis of variance indicate no significant differences in plasma levels of PTX3, VCAM-1 and CRP between PCI and CABG patients in response to acute aerobic exercise. Conclusion: plasma concentration of VCAM-1 increased in response to acute exercise in CAD patients after revascularization intervention but plasma levels of pentraxin superfamily bi-omarkers did not change significantly.