To comparatively analyze the endoscopic treatment of gastrointestinal polyps and explore the impact factors of hemorrhage after endoscopic treatment. To choose 150 patients with gastrointestinal polyps from January 2019 year to December 2021 year. According to endoscopic treatment, there were cold snare polypectomy (CSP), endoscopic mucosal resection (EMR), and endoscopic submucosal dissection (ESD). To analyze the complication among different endoscopic treatments and the impact factors of hemorrhage after endoscopic treatment. There were no significant differences in the characteristics of each treatment group. CSP and EMR have been used primarily in patients with proliferative and inflammatory polyps. However, using EMR and ESD, patients were mainly assessed for tubular adenoma, villous adenoma, and low-grade intraepithelial neoplasia. Subsequently, the ESD was mainly applied in patients with high-grade intraepithelial neoplasia. The risks of infection and bleeding in the EMR and ESD methods were higher than in the CSP method. The impact factors of hemorrhage after endoscopic treatments included therapeutic method, the diameter of polyps, smoking, and drinking. The main endoscopic treatments of gastrointestinal polyps included CSP, EMR, and ESD. The risks of infection and bleeding of EMR and ESD methods were increased. The impact factors of hemorrhage after endoscopic treatments included therapeutic method, the diameter of polyps, smoking, and drinking.