The effect of F. vulgaris extract on Streptozotocin-induced diabetic rats Download PDF

Aim: Medical plants are more importance in the treatment of diabetic complications. Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. F. vulgaris (FV) might have a various pharmacological effects. Objective: This study was designed to evaluate effect of hydro-alcoholic extract of FV against Streptozotocin (STZ)-induced diabetic rats on blood concentrations of glucose, insulin, nitric oxide and sirtuin1 gene expression in heart tissue. Material and Method: In this experimental study, diabetes animals were induced by STZ (60 mg/kg). 68 male rats were divided in to 8 groups. Including saline group, non-diabetic by various doses of FV (50, 100, 150 mg/kg) and diabetic plus FV(50, 100, 150 mg/kg) treatment groups were injected interaperitoneally once a day for 28 consecutive days. Body weight, blood concentrations of glucose, insulin, nitric oxide and sirtuin1 gene expression in heart tissue were measured and compared. Results: The results indicated that STZ administration significantly decreased sirtuin1 gene expression, Body weight, insulin serum level and increase blood concentrations of glucose and nitric oxide compared to saline group (p<0.05). However, in the FV and diabetic plus FV groups significantly decrease nitric oxide and glucose level (p<0.05), while significantly boosted sirtuin1 gene expression, Body weight and insulin serum level in all doses compared to diabetic group (p<0.05). Discussion: It seems that administration of F. vulgaris exerts appropriate, useful changes and improves diabetic -induced adverse effects in diabetic rats.