Currently, the interest in the synthesis of metallic nanoparticles has increased a lot because these systems are suitable to be used in distinct fields such as medical, pharmaceutical, agricultural, environmental protection, etc. Their synthesis can be done using different agents such as bacteria, fungi, and yeasts or using plant extracts and fresh plants. This paper aims to synthesize metallic silver (AgNPs) and selenium (SeNPs) nanoparticles using the fresh plant Stellaria media (L.) Vill (SM). Also, the synthesis of the metal nanoparticles is demonstrated by using the spectrophotometric method, then being characterized in terms of their size and distribution by DLS. Thus, it was demonstrated that the obtained AgNPs are smaller than SeNPs with dimensions between 28 nm and 255 nm from which 81.56% presented a diameter lower than 100 nm. In this paper, the total content of polyphenols was determined by using the Folin-Ciocalteu method, and the DPPH and FRAP methods demonstrated the antioxidant capacity of the SM plant. The obtained results were correlated with other results from the specialized literature and thus it was demonstrated that the SM plant acted as a reducing agent having an essential role in reducing the metal from the two salts (AgNO3 and Na2SeO3), thus taking place the synthesis of the metal nanoparticles. The antimicrobial effect of the SM plant extract has also been demonstrated, so in the future, we want to test in vitro the antimicrobial and repairing effect on the skin of the synthesized AgNPs and SeNPs