Effective diabetes self-management leads to blood glucose control, reduced morbidity and early mortality in adolescents with type 1 diabetes. Different factors affect the self-management of diabetes whose role and effect is still unknown. Among the influential factors whose effect is vague is spiritual intelligence, this study aims to investigate the predictive role of spiritual intelligence Diabetes management has been implemented in adolescents with type 1 diabetes. Materials and Methods: In this cross-sectional study, 200 adolescents with type 1 diabetes who referred to the Iranian Diabetes Association were enrolled in the study in 2016. The criteria for entering the study were: aged 15 to 21 years, diagnosis of diabetes for more than a year, full knowledge of the patient, illness, non-communicable diseases and psychotropic drugs. Results: Mean score of self-management of diabetes and spirituality was 86.1 ± 15.1 and 60.42 ± 12.9, respectively. Linear regression test (ANOVA: 0.002, F: 9.839) showed that spiritual intelligence can predict only 4.7% of diabetes self-management changes and its effect on diabetes self-management (Beta: 0.218).