Pharmacophore an International Research Journal
The primary aim of this systematic review is to examine the published research on the connection between cold exposure and ischemic heart disease (IHD). We conducted a systematic search through PubMed, Web of Science, Science Direct, EBSCO, and the Cochrane library. Using Rayyan QCRI, study articles were first screened by title and abstract before a full-text analysis was implemented. A total of six studies with 281979 patients were included. We comprised various cold events, including cold work environments among workers, cold spells, usual cold exposure, and prolonged extreme cold. Two studies reported that cold exposure among workers and the general population increases the risk of mortality rate due to myocardial infarction (MI). In CAD patients, prolonged severe cold exposure worsens coronary events (signs and symptoms). This comprehensive review indicated that exposure to the cold increased the risk of MI-related death in both workers and the general population. Furthermore, continuous exposure to extremely cold conditions makes coronary events worse in people with CAD.
