The Role of Inflammation in Early and Late Phase of Parkinson Disease Download PDF

This study aimed at exploring the role of inflammation in different stages of PD in a sample of PD patients in Al Madinah city, Saudi Arabia, and to identify the relationship between disease duration and level of the inflammatory markers. 22 Parkinson disease (PD) patients in Al Madinah City were subjected to a cross-sectional analysis. Motor and non-motor symptoms evaluation was carried out using the Unified Parkinson's Society Movement Disorders Rating Scale (NMSS) and the Hoehn and Yahr stages. Serum samples and C-reactive protein (CRP), erythrocytes (ESR), and IL-1 levels were measured, were taken.

The mean level of CPR was significantly positive concerning the length of the PD, (NMSS), Hoehn-Yahr, and ESR, and important concerning Hoehn and Yahr. The average ESR level for participants was substantially positively correlated, with both the NMSS and the average IL-1 levels, although there was a substantial negative correlation between the average level IL-1 and the mean level Unified Parkinson's (UPDRS). This study recommended future studies done on larger samples that include comprehensive and combined biomarkers for effective PD diagnosis and treatment.