The rs1801131 and idiopathic male infertility in Iranian population: a meta-analysis Download PDF

Methylene tetrahydrofolate reductase (MTHFR) gene is a key regulatory enzyme in folate pathway which is involved in male reproductive system. There are many single nucleotide polymorphism (SNP) in this gene. One of key gene polymorphisms is rs1801131 which may influence male infertility. The aim of this study is to investigate the association of rs1801131 with male infertility in Iranian population by a meta-analysis approach. To find out eligible studies, we searched appropriate universal (PubMed, Google Scholar, and ScienceDirect) and Persian (SID and Magiran) databases. After screening of articles, we analyzed the extracted data by Meta Analyst software. After meta-analysis, we didn’t find any significant association of rs1801131 with male infertility within Iranian population in CC vs. AA (OR= 1.088, 95%CI= 0.668-1.772, p= 0.735) and AC vs. AA (OR= 1.021, 95%CI= 0.742-1.406, p=0.897) genetics models. According to the result, we concluded that rs1801131 could not be a suitable biomarker for idiopathic male infertility in Iranian population.