Identifying the risk factor for the source of various diseases and disorders are essential for its early diagnosis and prevention. Serum uric acid (SUA) level has been suggested to be associated with various diseases including diabetes, cardiovascular diseases, hypertension, multiple sclerosis, hypothyroidism, obesity related factors, renal failure etc. Although elevated serum levels of uric acid in patients with various diseases or in those receiving maintenance of specific therapy like dialysis, the clinical impact of uric acid on mortality patients remain unknown. An epidemiological link between elevated serum uric acid and an increased cardiovascular risk has been recognized for many years. Some studies also highlighted the elevated serum uric acid concentrations are also found in healthy offspring of the parents with heart diseases, indicating a possible casual relationship. However, increased serum uric acid level is also associated with possible confounding factors including elevated serum triglyceride, cholesterol concentrations, blood glucose, fasting and post carbohydrate plasma insulin concentrations, waist hip ratio and body mass index. Thus this review highlighted the importance of detecting raised uric acid in serum as a powerful risk marker for various diseases that cause mortality.