Thiosemicarbazones and their metal complexes have numerous biological applications. Most of the studies reported the biological activities of thiosemicarbazones and their metal complexes. But not much reports have been existing about the anti-fungal properties of thiosemicarbazones. In this present study we reported the anti-fungal properties of nine newly synthesized thiosemicarbazones and their copper (II) complexes. For this purpose, we examined the anti-fungal activity of thiosemicarbazones and their copper (II) complexes on Candida albicans and Candida trophicalis. All the thiosemicarbazones and their metal complexes has taken in four different concentrations. All the results obtained are presented in table and analyzed with the help of graphs.