Pharmacosomes is a potential approach in vesicular drug delivery system which exhibits several advantages over conventional vesicular drug delivery systems. To improve the water solubility, bioavailability and minimize the gastrointestinal toxicity of ketoprofen, its pharmacosomes were prepared. Ketoprofen was complexed with phosphatidylcholine in various ratios using conventional solvent evaporation method. Pharmacosomes thus prepared were subjected to solubility and drug content evaluation, scanning electron microscopy, differential scanning calorimetry, X ray powder diffraction, in-vitro dissolution and in-vitro diffusion study. Pharmacosomes of ketoprofen were found to be disc shaped with rough surface in scanning electron microscopy. Solubility and in-vitro dissolution profile of pharmacosomes was found to be much better than ketoprofen. Drug content was found to be 99.8% and shown high % of drug loading. Differential scanning calorimetry thermograms and X-ray powder diffraction data’s confirmed the formation of phospholipid complex. In-vitro diffusion rate of ketoprofen from pharmacosomes was significantly higher. After 24 h, maximum drug was released from formulation PC4 is 55.3%. The release experiments clearly indicated sustained release of ketoprofen from pharmacosomal formulations.