Archive \ Volume.4 2013 Issue 5

DESIGN, FORMULATION AND EVALUATION OF A POLYHERBAL OINTMENT FOR ITS WOUND HEALING ACTIVITY

Kavitha AN , Deepthi V and Naira Nayeem
Abstract

The present study was aimed at designing, formulating and evaluating a polyherbal ointment comprising of methanolic extracts of the leaves of Tectona grandis, Ficus religiosa and Caesalpinia pulcherrima. The parameters evaluated for wound healing were period of contraction and tensile strength using excision and incision models. The animals were divided into groups and were treated with polyherbal formulation, standard group and one served as control group. Nitrofurazone (0.2% w/w) was used as reference standard. The period of epithelization in the excision wound mode was found to be 13.20 days, while in case of incision wound model the tensile strength was 540 when compared to the controls ,the results were extremely significant. Different parameters like pH, viscosity, spreadability and stability were evaluated. The formulation showed good spread ability, good consistency, homogeneity, there was no change in the appearance, pH, and no phase separation noticed at the end of the stability studies. There was no evidence of skin irritation. This study has revealed that the poly herbal ointment has shown the wound healing effect due to the synergistic activity of the phytoconstituents present in the extracts and may be used a potential herbal formulation for wound healing.