Introduction: Self-care plans and its related strategies are very important in patients who deal with chronic diseases. By learning the self-care skills, the patients can enhance their daily performances and wellness and treatment process of the disease. Purpose: This study is conducted with the aim of evaluating the effects of self-care Training through a group discussion method on hope rate of patients of Jahrom MS center in the year 2016. Materials and methods: this study is cross-sectional, descriptive analytic type which studies 30 patients of Jahrom MS society. Data are gathered through questionnaire of self-care index and Miller Hope Scale. SPSS23 software is used and inferential statistical tests (independent t-test) with significance level of P<0.05 are used for data analysis. Results: The findings show that 57.7% of the individuals’ hope rate is equal to 200 or higher than that which indicates that they are hopeful. Also after self-care and group discussion activities the hope rate average is increased to a significant statistical difference (P<0.05). Conclusion: Self-care through group discussion can raise hope rate in MS patients. Hope is fundamental to personality formation, and is essential for life. Since the majority of the studied MS societies were poor in terms of self-care, it is recommended to pay more attention to self-care programs for MS patients and eradicate the causes and factors which lead to poor self-care.