Sickle Cell Disease (SCD) is a genetic disease which affects the red blood cell. Its treatment of is very expensive and some patients go towards the traditional medicine. This work was undertaken to describe sickle patients from some area of Cameroon manage SCD using local food and medicinal plants. Five Cameroon regions which include West; Littoral; Center; East and North were visited and information collected through interview and observation. One hundred and seven families of patients with Sickle Cell Disease families visited answer the information survey. The results of this investigation revealed that the local black beans seeds (Phaseolus vulgaris L.) were used by 21 families in the West region while 8 of them used mill wild variety (Fragaria vesca L.). In the Littoral region, 23 families used bitter kola (Garcinia kola H.) and 8 seeds of Annona muricata L. Bitter kola (Garcinia kola H.) is also used by 23 families in Center and 14 in the East regions. The oil of the seeds of neem (Azadirachta indica J.) is used to manage SCD in 10 families in North Cameroon. Administration of these remedies was per os as food or decoction. Present findings provides basis for future research in anti-sickle cell drug development.