Pharmacophore an International Research Journal
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Open Access | Published: 2012 - Issue 1

EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF NOVEL SYNTHESIZED PYRROLE, PYRROLOPYRIMIDINE AND SPIROPYRROLOPYRIMIDINE DERIVATIVES Download PDF


Mosaad Sayed Mohamed, Ayman Goudah Mostafa2 and Rania Helmy Abd El-hameed1
Abstract

Some new pyrrole, pyrrolo[2,3-d]pyrimidine and spiro pyrrolo[2,3-d]pyrimidine derivatives were synthesized and identified by IR, 1H NMR, MS and elemental analysis. Most of the newly synthesized compounds were tested for their in vivo anti-inflammatory activity. Among them, compounds 4a-d, 5b-d and 8d are active compared to the activity of ibuprofen.

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Pharmacophore
ISSN: 2229-5402


Pharmacophore
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