Pharmacophore an International Research Journal
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Open Access | Published: 2016 - Issue 1

METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ORLISTAT BULK DRUG USING HYDROXYLAMINE SOLUTION BY VISIBLE SPECTROSCOPY Download PDF


Alekhya Prasanna, Suman Pattanayak and K Padmalatha
Abstract

A simple, precise, accurate visible spectroscopic method was developed and validated for the determination of Orlistat by using Hydroxylamine reagent and ferric chloride solution in co-solvent ethanol and subsequently diluted with distilled water. At the λmax of 515 nm, it was proved linear in the range 5-15 μg/ml, and exhibit good correlation coefficient (R2 =0.9978) and excellent mean recovery (98.82-102.3% w/w). The developed method was validated for accuracy, precision, robustness, ruggedness according to ICH guidelines. All these parameters showed adaptability of the method for the quality control analysis of Orlistat API.

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Pharmacophore
ISSN: 2229-5402

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