Pharmacophore an International Research Journal
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Open Access | Published: 2012 - Issue 1

NEW THEOPYRIMIDINE DERIVATIVES OF EXPECTED ANTIINFLAMMATORY ACTIVITY Download PDF


Mosaad Sayed Mohamed, Samir Mohamed Awad, Yasser Mohamed Zohny and Zainab Mahmoud Mohamed
Abstract

The pyrimidine derivatives 1-(4-aryl-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-yl)-ethanone (1a-c) were obtained from the reaction of thiourea with acetylacetone and aromatic aldehydes and utilized for synthesis of a number of thiopyrimidine derivatives (2a-i to 6a-f). Some of the newly synthesized compounds were preliminary tested for their antibacterial activity, and several compounds were tested for anti-inflammatory activity. Compounds, 4-aryl-6-methyl-5-(1-(arylimino) ethyl)-1, 2,3,4-tetrahydropyri-
midine-2(1H)-thiones 2a, 2c, 2f, 2i, 1-(4-aryl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-yl)-3-(arylamino)-propan-1-ones 3c, 3f and 6-methyl-4-styryl-5-(5-(2-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro pyrimidine-2-(1H)-thione (5b) were found to be effective as anti-inflammatory agents in vivo.

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Pharmacophore
ISSN: 2229-5402


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