Archive \ Volume.3 2012 Issue 3

STUDY THE EFFECT OF VARIOUS CARRIERS ON THE SOLUBILITY OF ACECLOFENAC

Bachhav Devidas G , Phatangare Kundan E. , Deore Leena P , Nikam.Komal R , Patil Unnatee S. and Namrata D.
Abstract

Aceclofenac is a new non-steroidal anti-inflammatory drug (NSAID) having fewer side effects as compared to other NSAIDs. The drug suffers from poor bioavailability due to its poor aqueous solubility. Aqueous solubility plays an important role in the dissolution of drug in the gastrointestinal fluid. The present study investigates the use of various carriers like PVP K-30, PEG-6000, Mannitol and Lactose with respect to their effect in increasing the solubility of Aceclofenac and improves its bioavailability.