Archive \ Volume.5 2014 Issue 5

THEORETICAL APPROACH FOR LIGAND BASED DRUG DESIGN OF LPXC: A KEY ENZYME OF LIPID A BIOSYNTHESIS

Shyamal Sharma , Uttam Kumar Mondal , Subhasis Mukhopadhyay and Asim Kumar Bothra
Abstract

Lipid A is an essential component of the outer membranes of the gram negative bacteria and genetic evidence has established that inhibition of its biosynthesis is lethal to gram-negative bacteria. It is seen that hydrophobicity is very important factor for the activity of LpxC inhibitors. Regression model developed in this work may be essential step for further development in designing and synthesis of good LpxC inhibitors.


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