Introduction: Acute epiglottis is a life-threatening condition that can lead to early death if not treated immediately. It is thought that acute epiglottis is a condition that can only affect children; however, adults also can be affected by it. Acute epiglottis can be infectious or non-infectious. The treatment is early intubation for severe cases. Objective: The objective of this review is to discuss acute epiglottis, its clinical and radiological manifestations, and how to deal with it to save the patient’s life. Method: We searched the PubMed database looking for articles relevant to the topic using Mesh terms, "Acute Epiglottis”. Conclusion: Proper history taking, and examination, and radiological study can protect patients from possible loss of their lives since it is an acute life-threatening condition that can lead to rapid deterioration of the patient’s life.