The current study focuses on the moderated moderation effect of gender and knowledge of caregivers about Schizophrenia on the relation between the Burden of Care (BOC) and Quality of Life (QOL). Data for the present study were collected from 150 caregivers of Schizophrenic patients using the snowball-sampling technique. Moderated moderation among the study variables was examined using a procedure developed by Dr.Andrew Hayes commonly known as ‘PROCESS’ which works with SPSS. The results of the study revealed that Knowledge significantly moderates the relation between BOC and QOL, but this moderation is moderated by the gender of the caregivers. For a visual representation of the moderation and moderated moderation effects, relevant graphs are produced. Results of the current study will provide guidelines for medical practitioners in devising such training programs, that shall simultaneously, reduce BOC and enhance QOL for caregivers of Schizophrenic patients keeping in view the gender of the caregivers. For the present study easy-to-follow approach is adopted with minimum cognitive jumps so that the procedure of the study can be replicated using other health care variables.