Study of the Toxicity of the Drug Monizen® Forte Download PDF

The article presents the results of studying the acute toxicity of the drug Monizen^® forte with the intragastric and subcutaneous route of administration to white male mice. Determination of the parameters of acute toxicity of the drug MONIZEN^® forte was carried out in the laboratory of pharmacology and toxicology and vivarium of VNIIVSGE-a branch of the FGBNU FNC VIEW RAN. Toxicological studies were carried out according to the «Guidelines for conducting preclinical studies of drugs. Part one» (2012.

The LD₅₀ value of MONISEN^® forte when administered parenterally (subcutaneously) to white nonlinear mice was 2524 ± 91.5 mg/kg and when administered orally (intragastrically) was 953.82 ± 156 mg/kg. According to the parameters of acute toxicity, established in mice, under the conditions of a single injection into the stomach, MONIZEN^® forte, according to the generally accepted hygienic classification GOST 12.1.007-76, belongs to the 3rd hazard class of moderately toxic compounds. The administration of overestimated doses of the drug MONIZEN^® forte white to nonlinear mice both parenterally and orally causes hepatotoxic and nephrotoxic effects.