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Open Access | Published: 2021 - Issue 2

Study of the Toxicity of the Drug Monizen® Forte Download PDF


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Abstract

The article presents the results of studying the acute toxicity of the drug Monizen® forte with the intragastric and subcutaneous route of administration to white male mice. Determination of the parameters of acute toxicity of the drug MONIZEN® forte was carried out in the laboratory of pharmacology and toxicology and vivarium of VNIIVSGE-a branch of the FGBNU FNC VIEW RAN. Toxicological studies were carried out according to the «Guidelines for conducting preclinical studies of drugs. Part one» (2012.

The LD50 value of MONISEN® forte when administered parenterally (subcutaneously) to white nonlinear mice was 2524 ± 91.5 mg/kg and when administered orally (intragastrically) was 953.82 ± 156 mg/kg. According to the parameters of acute toxicity, established in mice, under the conditions of a single injection into the stomach, MONIZEN® forte, according to the generally accepted hygienic classification GOST 12.1.007-76, belongs to the 3rd hazard class of moderately toxic compounds. The administration of overestimated doses of the drug MONIZEN® forte white to nonlinear mice both parenterally and orally causes hepatotoxic and nephrotoxic effects.

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Vancouver
Sergeevna EE, Ivanovich DV, Ivanovna PG, Anatolievich VA, Mikhailovna NA. Study of the Toxicity of the Drug Monizen® Forte. Pharmacophore. 2021;12(2):66-70. https://doi.org/10.51847/3BCqGpJb61
APA
Sergeevna, E. E., Ivanovich, D. V., Ivanovna, P. G., Anatolievich, V. A., & Mikhailovna, N. A. (2021). Study of the Toxicity of the Drug Monizen® Forte. Pharmacophore, 12(2), 66-70. https://doi.org/10.51847/3BCqGpJb61

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