Purpose of the work: to evaluate the results of surgical and combined (medical and surgical) treatment of patients with acromegaly. Materials and methods: 121 patients with a diagnosis of acromegaly (81 women (66.94%); 40 men (33.06%) were operated on. All patients were divided into 4 groups, comparable in terms of gender and age parameters: group 1 consisted of 30 patients (mean age of 46.89 ± 2.34 years) who underwent surgical treatment; group 2 included 30 patients (mean age of 47.01 ± 2.35 years) who received preoperative drug treatment with somatostatin analogues and underwent surgical treatment; group 3 consisted of 30 patients (mean age of 45.02 ± 2.25 years) who underwent surgical treatment and received postoperative drug treatment with somatostatin analogues; group 4 included 31 patients (mean age of 44.9 ± 2.25 years) who underwent surgical treatment and received drug treatment with somatostatin analogues both in the preoperative and postoperative periods. Observation of patients was carried out in the postoperative period (on the 7th day), as well as after 6 and 12 months. Results: In most cases, when using these methods of surgical intervention, a significantly greater number of total tumor resection was performed. The largest number of patients, in whom remission was registered after the surgical treatment, was observed after 12 months of observation (50% and 51% of cases, respectively, for each type of surgery). Pre- and postoperative administration of drug treatment (somatostatin analogs) increases the frequency of "remission in the entire group" up to 27.4%, reaching 96.7% in group. Conclusion: The use of combined methods of treatment contributed to the achievement of remission in a greater number of cases compared with only surgical treatment. Moreover, the largest number of patients who reached a state of remission was observed 12 months after the start of therapy.