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Open Access | Published: 2020 - Issue 5

Toxic Effect of Haloperidol on The Kidney of Chick Embryos Download PDF


Fawzyah Abdullah Mohammed Al-Ghamdi
Abstract

The kidney is a vital organ in the body and is severely affected by toxicant and poisonous substances and is considered the first organ that demonstrates the symptoms of drug toxicity. The current work aimed to investigate the impact of haloperidol treatment (0.25 mg/egg) on the renal development of chick embryos. The haloperidol was given at different developmental stages, at (5-day), the first week of incubation, and at (11-day) the first week of incubation, to study the teratogenic effect on the development of the kidney.  Also,  the morphological and histological studies were performed on the liver of 7-, 10-, 14-, and 16-day-old chick embryos treated with (0.25 mg/egg) of haloperidol at (zero, 5th, and 11th days) of incubation. Treatment with Haloperidol drug-induced retardation in the growth of the developing kidney of the treated chick embryos. The sign of retardation was observed in the treated kidney of chick embryos. The group that was injected on day zero was seriously influenced, followed by those injected on the 5-day incubation. The toxic effects of the drug were also observed more at 16-day treated chick embryos. It is concluded that that haloperidol has dangerous effects on kidney development with powerful toxicity on the cells, and the effect induced by the drug depends on the time of administration.

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Pharmacophore
ISSN: 2229-5402


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