The aim of the present study was to formulate a controlled release Ziprasidone HCl oral matrix tablet using different proportions of hydroxyl propyl methylcellulose (HPMC) K15M to minimize dosing frequency. Matrix tablets were prepared with various proportions of HPMC by direct-compression to upgrade their compliance and safety profile. Micromeritic properties of blends, physical evaluation of tablets, swelling, and dissolution studies were performed to optimize the formulation. The drug release profile indicated the controlled release pattern of formulation with HPMC K15M 50% for 24 hours effectively. Ziprasidone CR matrix-based tablet was formulated successfully and it was shown that the release of drugs could be controlled by the inclusion of different ratios of various viscosity grade polymers.