The article is devoted to enhancing the effectiveness of the treatment of chronic generalized periodontitis of mild severity, which is an important problem in modern dentistry. According to WHO, periodontitis is the most common therapeutic disease. The purpose of this study was to choose a method for the treatment of chronic generalized periodontitis of mild severity, in which a comparative analysis was performed between the traditional treatment method and the new generation M-chip preparation, which is a nanomatrix based on medical gelatin containing 0.07% miramistine solution. 54 patients participated in the study. According to the results of the study, the treatment of patients with the matrix showed a significant positive effect compared to those in conservative therapy.