Background and Objectives: Medical education is a well-known source of stress for medical students. It can affect their caloric intake leading to a change in their body weight. The current study aimed to decide the prevalence of stress among medical students and to observe the association between the level of stress, gender, and BMI among medical students at Taibah University, Medina. Aim of the study; To determine the prevalence of stress among medical students and to observe the association between the level of stress, gender, GPA, and BMI among medical students of Taibah University. Methods: A cross-sectional review was led at Taibah University that included all medical students from 2nd to 6th year. A perceived stress scale-10 questionnaire used to measure the stress score. Weight and height were collected based on self-reported value. Result: 257 of the students agreed take an interest in the review with a mean age of 21. 173 out of 257 were female students while 84 of them were male students. The prevalence of students with high stress was 23.3%. The higher level of stress was recorded among third-year female students however there was no statistically huge contrast amang gender. While the weight mass index (BMI) has been positively correlated with stress (p=0.010). Conclusion: Stress is prevalent between medical school students at Taibah University. We found a positive correlation between BMI and stress but no statistically significant association between gender and stress level. Preventive measures ought to be implanted to reduce the level of pressure between medical students.