Antiaging Effect of Tea Epigallocatechin Gallate and Its Role in Modifying Aging Epigenetics: A Systematic Review Download PDF

Increased life expectancy turns the public into aged societies, and aged individuals are expected to reach 2 billion of the world’s population. Aging is a time accumulating decline in the body's biological function. An important aging hallmark is epigenetic alteration. Tea is a rich source of Epigallocatechin Gallate which has a role in aging epigenetics modulation. This review is conducted to clarify and derive a more precise description of the association between Epigallocatechin Gallate (EGCG) and epigenetic alteration as an aging hallmark. The search was conducted in four databases (PubMed, Science Direct, Scopus, and Google Scholar) for peer-reviewed articles published between January 2011 and December 2020. Studies were selected according to the association between EGCG and regulation of aging-related epigenetic marks in mice animal models following the PRISMA statement checklist. The role of EGCG in muscle aging is the modification of miRNA, which decreases gene expression and proteins responsible for muscle wasting, another role of EGCG in aging through increasing AcH3K9 and HDAC1 lower expression, which improves cardiac diastolic function. EGCG is one of the epigenetics modifying phytochemicals in aging; according to the aging theory, histone acetylation restoration by HDAC 1 inhibitors, and there is a (gero-miRNAs) regulating aging-associated genes activity.