The present study aimed to design a sustained releasing and acting formulation of Domperidone with the aid of hydrophilic Methocel® K4M. Domperidone is an antiemetic drug used to treat nausea and vomiting. Generally, the dosing frequency is twice or thrice daily. Sustained- release formulation was prepared with different ratios of K4M. Furthermore, its quality and stability were determined. Pre-compression and post-compression characteristics were examined and the optimized formulation was selected for dissolution studies and also for similarity profiles. Drug dissolution studies revealed formulated tablet containing CF2 depicted the ideal release profile for once-daily consumption. Long-acting domperidone matrices were not just prepared but also displayed desirable properties required for an ideal once-daily formulation. The mechanism might be gel layer formation which afterward proceeded by gel erosion, hence giving a long slow-releasing pattern and desirable therapeutic effect. The concept of controlled release formulations helps the patients and care givers by reducing dosing frequency and chances of missed doses or overnight gap in administration of dose.