Pharmacophore an International Research Journal
Submit Manuscript
Open Access | Published: 2020 - Issue 3

Microrna-21 and the Role of Anti-Apoptosis in Human Cancers Download PDF

Minh Trong Quang, Kim My Thi Le, Tung Thanh Nguyen, Trinh Viet Nguyen, Tran Que Thi Tran, Hue Hong Thieu, Thuy Ai Huyen Le, Thuan Duc Lao

The dysregulation of miR-21 has been defined as the genome instability, an event of the hallmarks of cancer, is observed in human cancers. Additionally, the effect of dysregulation of miR-21 was observed in its target genes, which is involved in many signal pathways of tumorigenesis. Among them, particularly, miR-21 is strongly involved in the anti-apoptosis processes, also known as evading apoptosis. In the present study, we studied the experimentally validated miR-21 targets, including Bcl-2, PTEN, and PDCD4 gene, which are linked to anti-apoptosis in human cancers. Thus, miR-21 and its targeting apoptosis is a valuable therapeutic target in the development of human cancer treatment.

Cite this article

QR code:

Short Link:
Quick Access

ISSN: 2229-5402

Copyright © 2024 Pharmacophore
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.